Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type	Study_count
Total_Studies	1662
interventional	1461
Observational	173
Registry	28

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	597
Drug\|Other	111
Drug\|Radiation	67
Biological\|Drug	64
Procedure	51
Biological	48
Drug\|Procedure	47
Biological\|Drug\|Other	40
Device	39
Drug\|placebo	39
Radiation	38
Drug\|Other\|Radiation	31
Other	27
Drug\|Procedure\|Radiation	20
Drug\|Other\|Procedure	18
Biological\|Other	15
Device\|Drug	13
Drug\|Other\|placebo	11
Biological\|Drug\|Procedure	10
Biological\|Drug\|Radiation	10
Other\|Radiation	10
Diagnostic Test	9
Drug\|Other\|Procedure\|Radiation	9
Other\|Procedure	8
Biological\|Drug\|Other\|placebo	7
Other\|Procedure\|Radiation	7
Biological\|Drug\|placebo	6
Biological\|Drug\|Procedure\|Radiation	6
Biological\|Drug\|Other\|Procedure\|Radiation	5
Behavioral	4
Biological\|Drug\|Other\|Procedure	4
Biological\|Other\|Radiation	4
Combination Product	4
Dietary Supplement	4
Behavioral\|Other	3
Biological\|Other\|Procedure	3
Biological\|Procedure	3
Device\|Procedure	3
Dietary Supplement\|Drug	3
Drug\|Genetic	3
Drug\|Genetic\|Other	3
Drug\|Other\|placebo\|Procedure	3
Drug\|placebo\|Radiation	3
Genetic	3
Procedure\|Radiation	3
Behavioral\|Dietary Supplement\|Other	2
Behavioral\|Radiation	2
Biological\|Drug\|Other\|Radiation	2
Biological\|Other\|placebo	2
Combination Product\|Drug	2
Device\|Drug\|Other	2
Device\|Drug\|Procedure	2
Diagnostic Test\|Drug	2
Dietary Supplement\|Drug\|Other	2
Drug\|Genetic\|Other\|Procedure	2
Behavioral\|Device\|Other\|Procedure\|Radiation	1
Behavioral\|Other\|Procedure	1
Behavioral\|Procedure	1
Biological\|Combination Product	1
Biological\|Device\|Drug\|Other	1
Biological\|Drug\|Genetic\|Other	1
Biological\|Drug\|placebo\|Radiation	1
Biological\|Other\|Procedure\|Radiation	1
Biological\|placebo	1
Biological\|Radiation	1
Combination Product\|Other	1
Combination Product\|Other\|Procedure	1
Device\|Diagnostic Test	1
Device\|Drug\|Radiation	1
Device\|Other	1
Device\|Other\|Procedure\|Radiation	1
Device\|Procedure\|Radiation	1
Dietary Supplement\|Drug\|Other\|placebo\|Procedure	1
Dietary Supplement\|Drug\|Other\|placebo\|Radiation	1
Dietary Supplement\|Other\|placebo	1
Dietary Supplement\|Other\|placebo\|Procedure	1
Dietary Supplement\|placebo	1
Drug\|Genetic\|Other\|Procedure\|Radiation	1
Drug\|Other\|placebo\|Radiation	1
Genetic\|placebo	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country	Study_Count
United States	837
China	86
France	54
Korea, Republic of	40
Germany	38
Canada	32
United Kingdom	25
United States\|Canada	25
NA	22
Italy	16
Spain	15
United States\|Puerto Rico	8
Japan	7
Denmark	6
Belgium	5
Brazil	5
Netherlands	5
Russian Federation	5
Switzerland	5
Taiwan	5
Turkey	4
United States\|Canada\|Korea, Republic of	4
United States\|Japan	4
United States\|Spain	4
United States\|United Kingdom	4
Australia	3
Cuba	3
Egypt	3
India	3
Israel	3
Singapore	3
Sweden	3
United States\|Germany	3
United States\|Korea, Republic of	3
Australia\|New Zealand	2
Belgium\|Netherlands	2
Hong Kong	2
Iran, Islamic Republic of	2
Japan\|Korea, Republic of\|Taiwan	2
Norway	2
Poland	2
Portugal	2
United States\|Canada\|Israel	2
United States\|Canada\|Japan\|Korea, Republic of	2
United States\|Canada\|Puerto Rico	2
United States\|Canada\|Switzerland	2
United States\|France	2
United States\|France\|Germany	2
United States\|Israel	2
United States\|Japan\|Korea, Republic of	2
United States\|Mexico	2
United States\|Netherlands	2
Argentina	1
Australia\|Belgium\|Germany\|Netherlands\|Switzerland\|United Kingdom	1
Austria\|Belgium\|Denmark\|Germany\|Lithuania\|Netherlands\|Norway\|Spain\|Sweden	1
Austria\|Belgium\|Netherlands	1
Austria\|France\|Germany\|Hungary\|Switzerland	1
Austria\|Germany\|Spain\|United Kingdom	1
Belarus\|Hungary\|Poland\|Russian Federation\|Ukraine	1
Belgium\|Canada\|France	1
Belgium\|France\|Germany\|Hungary\|Netherlands\|Poland\|United Kingdom	1
Belgium\|France\|Germany\|Italy\|Poland\|Spain	1
Belgium\|France\|Netherlands\|Switzerland	1
Belgium\|Norway	1
Belgium\|United Kingdom	1
Bosnia and Herzegovina\|Croatia\|Korea, Republic of\|Spain\|Taiwan\|United Kingdom	1
Brazil\|Canada\|Cyprus\|United Kingdom	1
Canada\|France	1
China\|Korea, Republic of\|Malaysia\|Taiwan	1
China\|Korea, Republic of\|Thailand	1
China\|Malaysia\|Philippines\|Thailand	1
Czech Republic\|Hungary\|Ukraine	1
Czechia	1
Czechia\|France\|Germany\|Israel\|Italy\|Norway\|Poland\|Portugal\|Spain\|United Kingdom	1
Denmark\|France\|Ireland\|United Kingdom	1
Denmark\|France\|Sweden\|United Kingdom	1
Denmark\|Netherlands\|United Kingdom	1
Finland\|Sweden	1
France\|Germany	1
France\|Martinique	1
France\|Spain	1
France\|United States\|Belgium\|China\|Germany\|Hong Kong\|Italy\|Korea, Republic of\|Netherlands\|Singapore\|Spain\|Taiwan\|United Kingdom	1
Georgia\|Hong Kong\|India\|Moldova, Republic of\|Serbia\|Taiwan\|Thailand\|Ukraine	1
Germany\|Latvia	1
Germany\|Netherlands	1
Germany\|Spain\|Switzerland	1
Germany\|Switzerland	1
Germany\|United States\|Australia\|Belgium\|Canada\|France\|Israel\|Italy\|Korea, Republic of\|Netherlands\|Spain\|United Kingdom	1
Greece	1
Hong Kong\|United States\|Belgium\|Brazil\|Czech Republic\|Egypt\|France\|Germany\|Hungary\|Italy\|Korea, Republic of\|Netherlands\|Russian Federation\|Singapore\|South Africa\|Spain\|Switzerland\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
Japan\|Korea, Republic of	1
Jordan\|Lebanon	1
Latvia\|Turkey\|Hungary	1
Lithuania	1
Norway\|Sweden	1
Poland\|Ukraine	1
Russian Federation\|Bulgaria\|Czechia\|Germany\|Latvia\|Ukraine	1
Saudi Arabia	1
Spain\|Australia\|Canada\|China\|France\|Germany\|Hong Kong\|Ireland\|Korea, Republic of\|Norway\|Singapore\|Sweden\|Taiwan\|United Kingdom	1
Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|Chile\|France\|Germany\|Hong Kong\|Hungary\|Ireland\|Italy\|Japan\|Korea, Republic of\|Malaysia\|Peru\|Philippines\|Romania\|Russian Federation\|Taiwan\|Thailand\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Canada\|France\|Germany\|Italy\|Netherlands\|Norway\|Russian Federation\|Sweden\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Bosnia and Herzegovina\|Brazil\|Canada\|Chile\|Colombia\|Croatia\|Czechia\|Egypt\|Guatemala\|India\|Indonesia\|Italy\|Korea, Republic of\|Lebanon\|Malta\|Mexico\|New Zealand\|Philippines\|Poland\|Romania\|Russian Federation\|South Africa\|Spain\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|France\|Hungary\|New Zealand\|Poland\|Romania\|Russian Federation\|Slovakia\|Turkey\|United Kingdom	1
United States\|Argentina\|Austria\|Canada\|China\|Croatia\|Greece\|Ireland\|Japan\|Korea, Republic of\|Malaysia\|Netherlands\|Portugal\|Romania\|Spain\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
United States\|Argentina\|Belgium\|Canada\|Czechia\|Denmark\|Finland\|France\|Germany\|Hungary\|Israel\|Italy\|Japan\|Mexico\|Netherlands\|Poland\|Puerto Rico\|Russian Federation\|Spain\|United Kingdom	1
United States\|Argentina\|Belgium\|Canada\|France\|Germany\|Netherlands\|Poland\|United Kingdom	1
United States\|Australia	1
United States\|Australia\|Austria\|Belgium\|Canada\|China\|Czechia\|France\|Germany\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Poland\|Portugal\|Russian Federation\|Singapore\|Spain\|Taiwan\|Ukraine	1
United States\|Australia\|Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Russian Federation\|Spain\|Ukraine	1
United States\|Australia\|Belgium\|Brazil\|Canada\|Chile\|China\|Colombia\|France\|Germany\|Israel\|Italy\|Japan\|Korea, Republic of\|Mexico\|Peru\|Poland\|Spain\|Taiwan\|United Kingdom	1
United States\|Australia\|Belgium\|Brazil\|Canada\|Czech Republic\|Greece\|Korea, Republic of\|New Zealand\|Poland\|Portugal\|Romania\|Russian Federation\|Spain	1
United States\|Australia\|Belgium\|Brazil\|Czechia\|France\|Germany\|Hungary\|Italy\|Spain	1
United States\|Australia\|Belgium\|Canada\|Germany\|Italy\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Hong Kong\|Italy\|Korea, Republic of\|Poland\|Russian Federation\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Chile\|Colombia\|Czechia\|France\|Germany\|Hungary\|Italy\|Peru\|Poland\|Romania\|Spain\|Turkey\|United Kingdom	1
United States\|Australia\|Belgium\|Czechia\|France\|Germany\|Italy\|Korea, Republic of\|Poland\|Spain	1
United States\|Australia\|Belgium\|France\|Hungary\|Italy\|Poland\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|France\|Israel\|Spain\|Taiwan\|United Kingdom	1
United States\|Australia\|Brazil\|Canada\|Chile\|China\|Colombia\|France\|Guatemala\|Hong Kong\|Ireland\|Israel\|Japan\|Korea, Republic of\|Mexico\|New Zealand\|Peru\|Poland\|Russian Federation\|South Africa\|Spain\|Switzerland\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
United States\|Australia\|Brazil\|Canada\|France\|Germany\|Hungary\|Italy\|Japan\|Korea, Republic of\|Romania\|Russian Federation\|Spain\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
United States\|Australia\|Brazil\|Chile\|China\|France\|Germany\|Guatemala\|Ireland\|Israel\|Italy\|Japan\|Korea, Republic of\|New Zealand\|Poland\|Russian Federation\|Spain\|Turkey\|Ukraine\|United Kingdom	1
United States\|Australia\|Canada\|Germany\|Italy\|Poland\|Russian Federation\|Spain	1
United States\|Australia\|Canada\|Ireland\|New Zealand\|Peru\|Puerto Rico\|United Kingdom	1
United States\|Australia\|Canada\|Japan\|Singapore\|Spain\|United Kingdom	1
United States\|Australia\|China\|Japan	1
United States\|Australia\|France\|Ireland\|Italy\|Japan\|Korea, Republic of\|Spain\|Taiwan	1
United States\|Australia\|France\|Japan	1
United States\|Australia\|Korea, Republic of\|Taiwan	1
United States\|Australia\|New Zealand\|Poland\|Thailand	1
United States\|Australia\|Norway\|Spain	1
United States\|Australia\|Singapore	1
United States\|Australia\|Spain	1
United States\|Austria\|Canada\|Czechia\|France\|Hungary\|Israel\|Italy\|Poland\|Spain\|Switzerland	1
United States\|Belgium	1
United States\|Belgium\|Brazil\|Canada\|Chile\|France\|Germany\|Israel\|Italy\|Japan\|Korea, Republic of\|Malaysia\|Poland\|Russian Federation\|Singapore\|Taiwan\|Ukraine\|United Kingdom	1
United States\|Belgium\|Canada\|Czechia\|Germany\|Greece\|Italy\|Spain\|Sweden\|Turkey\|Ukraine	1
United States\|Belgium\|Canada\|France\|Israel\|Italy\|Singapore\|Spain\|Taiwan	1
United States\|Belgium\|Canada\|Israel	1
United States\|Belgium\|Canada\|Spain	1
United States\|Belgium\|France\|Germany\|Italy\|Korea, Republic of\|Spain\|United Kingdom	1
United States\|Belgium\|Italy	1
United States\|Belgium\|Italy\|Spain\|United Kingdom	1
United States\|Belgium\|Korea, Republic of\|Netherlands\|Poland	1
United States\|Belgium\|United Kingdom	1
United States\|Bulgaria\|Poland\|Romania\|Russian Federation\|Ukraine	1
United States\|Canada\|France	1
United States\|Canada\|France\|Germany\|Hungary\|Spain	1
United States\|Canada\|France\|Germany\|Mexico\|Poland\|Russian Federation	1
United States\|Canada\|France\|Netherlands	1
United States\|Canada\|France\|Netherlands\|United Kingdom	1
United States\|Canada\|Germany\|Korea, Republic of\|Netherlands\|Spain	1
United States\|Canada\|Hong Kong	1
United States\|Canada\|Ireland\|Switzerland	1
United States\|Canada\|Japan\|Korea, Republic of\|Puerto Rico	1
United States\|Canada\|Japan\|Korea, Republic of\|Singapore\|Taiwan	1
United States\|Canada\|Peru\|Puerto Rico\|South Africa	1
United States\|Canada\|Peru\|South Africa	1
United States\|Canada\|Singapore	1
United States\|Chile\|Denmark\|Estonia\|France\|Hungary\|Italy\|Korea, Republic of\|Russian Federation\|Taiwan\|Turkey	1
United States\|China\|France\|Italy\|Japan\|Korea, Republic of\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Spain\|Taiwan\|Turkey\|United Kingdom	1
United States\|Czech Republic\|France\|Poland\|Spain\|United Kingdom	1
United States\|Denmark\|France\|Spain	1
United States\|Finland\|Netherlands\|Sweden\|United Kingdom	1
United States\|France\|Germany\|Hong Kong\|Italy\|Japan\|Korea, Republic of\|Poland\|Russian Federation\|Singapore\|Spain\|Taiwan	1
United States\|France\|Germany\|Israel\|Italy\|Korea, Republic of\|Spain\|Taiwan	1
United States\|France\|Germany\|Italy\|Japan\|Korea, Republic of\|Poland\|Romania\|Russian Federation\|Taiwan\|Ukraine\|United Kingdom	1
United States\|France\|Germany\|Japan\|Spain\|United Kingdom	1
United States\|France\|Germany\|Korea, Republic of\|Netherlands\|Spain\|Taiwan\|United Kingdom	1
United States\|France\|Hungary\|Israel\|Korea, Republic of\|Romania\|Russian Federation\|Taiwan	1
United States\|France\|Israel\|Korea, Republic of	1
United States\|France\|Italy\|Korea, Republic of\|Taiwan	1
United States\|France\|United Kingdom	1
United States\|Germany\|Korea, Republic of\|Netherlands\|Spain\|Taiwan\|United Kingdom	1
United States\|Germany\|Korea, Republic of\|Spain	1
United States\|Hong Kong\|Japan\|Korea, Republic of\|Taiwan	1
United States\|Hong Kong\|Japan\|Singapore\|Taiwan	1
United States\|Hungary\|India\|Russian Federation\|Ukraine	1
United States\|Israel\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Chile\|Estonia\|France\|Germany\|Hungary\|Italy\|Japan\|Korea, Republic of\|Lithuania\|Mexico\|Poland\|Portugal\|Romania\|Russian Federation\|Singapore\|Spain\|Taiwan\|United Kingdom	1
United States\|Israel\|Korea, Republic of\|Spain	1
United States\|Italy	1
United States\|Korea, Republic of\|Spain\|United Kingdom	1
United States\|Netherlands\|Peru	1
United States\|Norway\|Spain\|United Kingdom	1
United States\|Peru\|South Africa	1
United States\|Russian Federation	1
United States\|South Africa	1
Vietnam	1

Sites per Study

Site_count	Study_Count
1	769
2	130
3	75
4	42
5	36
6	29
7	31
8	17
9	19
10	12
11	10
12	7
13	9
14	14
15	8
16	11
17	5
18	7
19	4
20	9
21	5
22	7
23	9
24	5
25	6
26	5
27	2
28	5
29	3
30	5
31	3
32	3
33	2
34	3
35	4
36	4
37	1
39	3
41	2
42	1
43	4
44	2
45	1
46	3
47	1
48	1
49	1
50	1
51	1
52	2
54	1
55	2
56	1
57	2
59	3
61	1
62	3
63	1
66	1
68	1
72	1
73	2
75	1
78	2
79	1
81	1
86	2
87	2
93	1
95	2
96	1
97	1
101	1
103	1
106	1
107	1
108	1
113	1
115	1
116	1
133	1
134	1
135	1
140	2
141	1
145	1
147	1
154	1
155	1
157	2
161	1
162	1
163	1
167	3
170	1
180	1
182	1
186	1
187	2
193	1
196	1
200	1
221	1
224	1
227	1
233	2
234	1
235	1
241	1
255	1
267	1
280	1
283	1
315	1
337	1
358	1
364	1
366	1
393	1
410	1
433	1
439	1
476	1
504	1
508	3
534	1
539	1
540	1
549	1
573	1
632	1
634	1
640	1
663	1
670	1
672	1
687	1
699	1
709	1
718	1
756	1
789	1
798	1
807	1
849	1
894	1
895	1
931	1
936	1
937	1
1230	1
1296	1
1498	1

Phase

Phase	Study_Count
Phase 2	658
Phase 1	265
N/A	176
Phase 3	153
Phase 1/Phase 2	148
Phase 2/Phase 3	25
Early Phase 1	23
Phase 4	13

Number of Arms

Number_of_Arms	Count_of_Studies
1	762
2	460
3	88
4	50
5	8
6	13
7	7
9	4
10	2
11	2
13	1
14	1
15	1
NA	62

Number of Updates

Count of Versions	Count of Studies
1	53
2	115
3	121
4	90
5	86
6	92
7	60
8	64
9	46
10	59
11	45
12	43
13	41
14	37
15	38
16	26
17	29
18	30
19	23
20	20
21	16
22	20
23	13
24	14
25	8
26	8
27	12
28	10
29	6
30	9
31	4
32	7
33	5
34	8
35	7
36	7
37	5
38	2
39	7
40	4
41	5
42	3
43	2
44	3
45	1
46	2
47	1
48	2
50	9
51	2
52	5
53	1
54	1
55	1
56	3
57	4
58	3
59	4
60	1
61	1
62	1
63	1
64	5
66	2
67	2
68	4
69	1
71	3
72	3
73	1
74	3
75	2
77	1
78	1
80	3
81	3
82	2
85	3
86	2
88	1
89	1
90	1
91	1
93	1
94	1
95	3
97	2
100	1
101	1
102	1
105	2
106	1
107	1
112	2
116	1
123	2
124	2
127	1
131	1
136	1
138	1
142	1
146	1
156	1
157	1
192	1
195	1
197	1
205	2
212	1
218	1
221	1
222	1
238	1
241	1
268	1
287	1
297	1
307	1
324	1
342	1
346	1
364	1
383	1
399	1
403	1
415	1
430	2
453	1
463	1
489	1
501	1
508	1
518	1
533	1
569	1
664	1
704	1
935	1
1073	1
1145	1
1228	1
1366	1
1521	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	41743	1408	29.647017
Contacts/Locations	23903	1314	18.191020
Recruitment Status	2762	1268	2.178233
Arms	2534	820	3.090244
Interventions	2534	820	3.090244
Eligibility	2489	854	2.914520
Study Design	2142	983	2.179044
Study Identification	2115	769	2.750325
Study Description	2051	729	2.813443
Outcome Measures	1857	839	2.213349
None (earliest Version on record)	1461	1461	1.000000
Conditions	1360	558	2.437276
Oversight	1314	754	1.742706
Sponsor/Collaborators	1180	679	1.737850
More Information	631	157	4.019108
References	588	273	2.153846
Results	250	250	1.000000
IPDSharing	188	163	1.153374
Results Submission Events	94	94	1.000000
Documents	88	85	1.035294
Baseline Characteristics	78	57	1.368421
Reported Adverse Events	53	48	1.104167
Participant Flow	45	40	1.125000
2020Recruitment Status	2	2	1.000000
Quality Control Review has not concludedReturned: June 9	1	1	1.000000
Quality Control Review has not concludedReturned: March 20	1	1	1.000000

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	8.00000	2.0000	1.00000	2.00000	1.00000	42.0000	5.0000	3.0000
1st Qu.	13.50000	25.0000	18.00000	34.75000	30.00000	123.7500	297.7500	40.0000
Median	19.00000	66.5000	28.00000	60.00000	50.00000	258.0000	496.0000	86.0000
Mean	20.95652	236.3068	43.14015	89.52027	82.17152	337.4583	734.0789	232.4615
3rd Qu.	30.00000	150.7500	45.00000	115.00000	90.00000	472.0000	766.5000	143.0000
Max.	37.00000	8300.0000	474.00000	527.00000	1400.00000	1408.0000	10273.0000	1030.0000

Trial Group Type

group_type	Group_Count
Experimental	1909
Active Comparator	345
Other	78
NA	62
Placebo Comparator	60
No Intervention	39
Sham Comparator	2

Intervention Model

intervention_model	Study_Count
Single Group Assignment	824
Parallel Assignment	547
Sequential Assignment	47
Crossover Assignment	21
NA	17
Factorial Assignment	5

Primary Purpose

primary_purpose	Study_Count
Treatment	1301
Diagnostic	80
Prevention	24
Supportive Care	15
Other	14
Health Services Research	10
Screening	7
Basic Science	5
NA	4
Device Feasibility	1

Observational Studies

Studies by Country

Country	Study_Count
United States	58
France	17
Italy	11
NA	11
United Kingdom	11
China	9
Canada	6
Belgium	5
Netherlands	4
Ireland	3
Korea, Republic of	3
Taiwan	3
Greece	2
Morocco	2
Spain	2
Algeria\|Morocco	1
Belgium\|Denmark\|France\|Germany\|Italy\|Netherlands\|Norway\|Romania\|Spain\|United Kingdom	1
Denmark	1
Denmark\|France\|Germany\|Italy\|Norway\|Romania\|Spain\|United Kingdom	1
France\|Belgium	1
France\|Germany\|Italy\|Japan\|Netherlands\|Spain\|Sweden\|United Kingdom	1
Germany	1
Germany\|Serbia\|United Kingdom	1
Hungary	1
Kazakhstan	1
Norway	1
Pakistan	1
Russian Federation	1
Serbia	1
Switzerland	1
Thailand	1
Turkey	1
United States\|Australia\|Canada	1
United States\|Canada\|Germany	1
United States\|Canada\|Hong Kong	1
United States\|Canada\|Spain\|Sweden\|United Kingdom	1
United States\|Israel	1
United States\|Netherlands	1
United States\|Netherlands\|United Kingdom	1
United States\|Puerto Rico	1
United States\|Switzerland	1

Sites per Study

Site_count	Study_Count
1	119
2	9
3	5
4	6
5	3
6	1
7	4
8	2
9	3
10	3
12	2
13	1
14	2
16	3
17	1
18	2
19	1
22	1
36	1
57	1
66	1
101	1
143	1

Number of Updates

Count of Versions	Count of Studies
1	38
2	32
3	22
4	14
5	9
6	12
7	4
8	7
9	4
10	2
11	6
12	2
13	1
14	3
16	1
17	2
18	3
20	2
21	1
24	2
51	1
52	1
54	1
66	1
72	1
110	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	1070	135	7.925926
Contacts/Locations	352	103	3.417476
None (earliest Version on record)	173	173	1.000000
Recruitment Status	143	90	1.588889
Study Design	136	81	1.679012
Study Description	131	51	2.568627
Eligibility	91	49	1.857143
Sponsor/Collaborators	70	44	1.590909
Groups	69	43	1.604651
Interventions	69	43	1.604651
Study Identification	69	41	1.682927
Outcome Measures	65	42	1.547619
Conditions	53	27	1.962963
Oversight	45	34	1.323529
IPDSharing	14	12	1.166667
References	11	8	1.375000
More Information	4	1	4.000000
Results	3	3	1.000000
Results Submission Events	1	1	1.000000

Enrollment Metrics

Measure	Observational
Min	3.000
1st Qu	58.000
Median	152.000
Mean	5035.756
3rd Qu	500.000
Max	684815.000

Observation Model

observational_model	Study_Count
Cohort	117
Case-Only	32
Case-Control	14
Other	4
Case Control	3
NA	2
Ecologic or Community	1

Time Perspective

time_perspective	Study_Count
Prospective	120
Retrospective	40
Cross-Sectional	9
Other	2
NA	2

Registries

Studies by Country

Country	Study_Count
United States	7
China	3
Germany	3
NA	3
Spain	2
Brazil	1
Canada	1
Denmark	1
France	1
Italy	1
Korea, Republic of	1
Luxembourg	1
Singapore	1
Sweden	1
United States\|Israel	1

Sites per Study

Site_count	Study_Count
1	22
2	2
4	1
6	1
7	1
17	1

Number of Updates

Count of Versions	Count of Studies
1	10
2	8
3	2
4	1
5	3
6	1
7	1
8	1
22	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	66	18	3.666667
Contacts/Locations	28	11	2.545454
None (earliest Version on record)	28	28	1.000000
Recruitment Status	11	10	1.100000
Study Design	11	9	1.222222
Sponsor/Collaborators	8	7	1.142857
Eligibility	3	1	3.000000
Groups	2	2	1.000000
Interventions	2	2	1.000000
IPDSharing	2	2	1.000000
Outcome Measures	2	2	1.000000
Oversight	2	2	1.000000
Study Description	2	2	1.000000
Study Identification	2	2	1.000000
Conditions	1	1	1.000000
References	1	1	1.000000

Enrollment Metrics

Measure	Registries
Min	8.000
1st Qu	89.750
Median	200.000
Mean	1865.893
3rd Qu	762.500
Max	31795.000

Registry Model

observational_model	Study_Count
Cohort	21
Case-Only	3
Other	2
Case-Control	1
Case Control	1

Time Perspective

time_perspective	Study_Count
Prospective	26
Cross-Sectional	1
Other	1

Follow-up

target_duration	Study_Count
5 Years	6
10 Years	4
2 Years	4
3 Years	4
1 Year	3
1 Month	2
12 Months	1
30 Days	1
8 Years	1
90 Days	1
99 Years	1

intervention_type	Study_Count
Drug	597
Drug\|Other	111
Drug\|Radiation	67
Biological\|Drug	64
Procedure	51
Biological	48
Drug\|Procedure	47
Biological\|Drug\|Other	40
Device	39
Drug\|placebo	39
Radiation	38
Drug\|Other\|Radiation	31
Other	27
Drug\|Procedure\|Radiation	20
Drug\|Other\|Procedure	18
Biological\|Other	15
Device\|Drug	13
Drug\|Other\|placebo	11
Biological\|Drug\|Procedure	10
Biological\|Drug\|Radiation	10
Other\|Radiation	10
Diagnostic Test	9
Drug\|Other\|Procedure\|Radiation	9
Other\|Procedure	8
Biological\|Drug\|Other\|placebo	7
Other\|Procedure\|Radiation	7
Biological\|Drug\|placebo	6
Biological\|Drug\|Procedure\|Radiation	6
Biological\|Drug\|Other\|Procedure\|Radiation	5
Behavioral	4
Biological\|Drug\|Other\|Procedure	4
Biological\|Other\|Radiation	4
Combination Product	4
Dietary Supplement	4
Behavioral\|Other	3
Biological\|Other\|Procedure	3
Biological\|Procedure	3
Device\|Procedure	3
Dietary Supplement\|Drug	3
Drug\|Genetic	3
Drug\|Genetic\|Other	3
Drug\|Other\|placebo\|Procedure	3
Drug\|placebo\|Radiation	3
Genetic	3
Procedure\|Radiation	3
Behavioral\|Dietary Supplement\|Other	2
Behavioral\|Radiation	2
Biological\|Drug\|Other\|Radiation	2
Biological\|Other\|placebo	2
Combination Product\|Drug	2
Device\|Drug\|Other	2
Device\|Drug\|Procedure	2
Diagnostic Test\|Drug	2
Dietary Supplement\|Drug\|Other	2
Drug\|Genetic\|Other\|Procedure	2
Behavioral\|Device\|Other\|Procedure\|Radiation	1
Behavioral\|Other\|Procedure	1
Behavioral\|Procedure	1
Biological\|Combination Product	1
Biological\|Device\|Drug\|Other	1
Biological\|Drug\|Genetic\|Other	1
Biological\|Drug\|placebo\|Radiation	1
Biological\|Other\|Procedure\|Radiation	1
Biological\|placebo	1
Biological\|Radiation	1
Combination Product\|Other	1
Combination Product\|Other\|Procedure	1
Device\|Diagnostic Test	1
Device\|Drug\|Radiation	1
Device\|Other	1
Device\|Other\|Procedure\|Radiation	1
Device\|Procedure\|Radiation	1
Dietary Supplement\|Drug\|Other\|placebo\|Procedure	1
Dietary Supplement\|Drug\|Other\|placebo\|Radiation	1
Dietary Supplement\|Other\|placebo	1
Dietary Supplement\|Other\|placebo\|Procedure	1
Dietary Supplement\|placebo	1
Drug\|Genetic\|Other\|Procedure\|Radiation	1
Drug\|Other\|placebo\|Radiation	1
Genetic\|placebo	1

Country	Study_Count
United States	837
China	86
France	54
Korea, Republic of	40
Germany	38
Canada	32
United Kingdom	25
United States\|Canada	25
NA	22
Italy	16
Spain	15
United States\|Puerto Rico	8
Japan	7
Denmark	6
Belgium	5
Brazil	5
Netherlands	5
Russian Federation	5
Switzerland	5
Taiwan	5
Turkey	4
United States\|Canada\|Korea, Republic of	4
United States\|Japan	4
United States\|Spain	4
United States\|United Kingdom	4
Australia	3
Cuba	3
Egypt	3
India	3
Israel	3
Singapore	3
Sweden	3
United States\|Germany	3
United States\|Korea, Republic of	3
Australia\|New Zealand	2
Belgium\|Netherlands	2
Hong Kong	2
Iran, Islamic Republic of	2
Japan\|Korea, Republic of\|Taiwan	2
Norway	2
Poland	2
Portugal	2
United States\|Canada\|Israel	2
United States\|Canada\|Japan\|Korea, Republic of	2
United States\|Canada\|Puerto Rico	2
United States\|Canada\|Switzerland	2
United States\|France	2
United States\|France\|Germany	2
United States\|Israel	2
United States\|Japan\|Korea, Republic of	2
United States\|Mexico	2
United States\|Netherlands	2
Argentina	1
Australia\|Belgium\|Germany\|Netherlands\|Switzerland\|United Kingdom	1
Austria\|Belgium\|Denmark\|Germany\|Lithuania\|Netherlands\|Norway\|Spain\|Sweden	1
Austria\|Belgium\|Netherlands	1
Austria\|France\|Germany\|Hungary\|Switzerland	1
Austria\|Germany\|Spain\|United Kingdom	1
Belarus\|Hungary\|Poland\|Russian Federation\|Ukraine	1
Belgium\|Canada\|France	1
Belgium\|France\|Germany\|Hungary\|Netherlands\|Poland\|United Kingdom	1
Belgium\|France\|Germany\|Italy\|Poland\|Spain	1
Belgium\|France\|Netherlands\|Switzerland	1
Belgium\|Norway	1
Belgium\|United Kingdom	1
Bosnia and Herzegovina\|Croatia\|Korea, Republic of\|Spain\|Taiwan\|United Kingdom	1
Brazil\|Canada\|Cyprus\|United Kingdom	1
Canada\|France	1
China\|Korea, Republic of\|Malaysia\|Taiwan	1
China\|Korea, Republic of\|Thailand	1
China\|Malaysia\|Philippines\|Thailand	1
Czech Republic\|Hungary\|Ukraine	1
Czechia	1
Czechia\|France\|Germany\|Israel\|Italy\|Norway\|Poland\|Portugal\|Spain\|United Kingdom	1
Denmark\|France\|Ireland\|United Kingdom	1
Denmark\|France\|Sweden\|United Kingdom	1
Denmark\|Netherlands\|United Kingdom	1
Finland\|Sweden	1
France\|Germany	1
France\|Martinique	1
France\|Spain	1
France\|United States\|Belgium\|China\|Germany\|Hong Kong\|Italy\|Korea, Republic of\|Netherlands\|Singapore\|Spain\|Taiwan\|United Kingdom	1
Georgia\|Hong Kong\|India\|Moldova, Republic of\|Serbia\|Taiwan\|Thailand\|Ukraine	1
Germany\|Latvia	1
Germany\|Netherlands	1
Germany\|Spain\|Switzerland	1
Germany\|Switzerland	1
Germany\|United States\|Australia\|Belgium\|Canada\|France\|Israel\|Italy\|Korea, Republic of\|Netherlands\|Spain\|United Kingdom	1
Greece	1
Hong Kong\|United States\|Belgium\|Brazil\|Czech Republic\|Egypt\|France\|Germany\|Hungary\|Italy\|Korea, Republic of\|Netherlands\|Russian Federation\|Singapore\|South Africa\|Spain\|Switzerland\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
Japan\|Korea, Republic of	1
Jordan\|Lebanon	1
Latvia\|Turkey\|Hungary	1
Lithuania	1
Norway\|Sweden	1
Poland\|Ukraine	1
Russian Federation\|Bulgaria\|Czechia\|Germany\|Latvia\|Ukraine	1
Saudi Arabia	1
Spain\|Australia\|Canada\|China\|France\|Germany\|Hong Kong\|Ireland\|Korea, Republic of\|Norway\|Singapore\|Sweden\|Taiwan\|United Kingdom	1
Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|Chile\|France\|Germany\|Hong Kong\|Hungary\|Ireland\|Italy\|Japan\|Korea, Republic of\|Malaysia\|Peru\|Philippines\|Romania\|Russian Federation\|Taiwan\|Thailand\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Canada\|France\|Germany\|Italy\|Netherlands\|Norway\|Russian Federation\|Sweden\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Bosnia and Herzegovina\|Brazil\|Canada\|Chile\|Colombia\|Croatia\|Czechia\|Egypt\|Guatemala\|India\|Indonesia\|Italy\|Korea, Republic of\|Lebanon\|Malta\|Mexico\|New Zealand\|Philippines\|Poland\|Romania\|Russian Federation\|South Africa\|Spain\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|France\|Hungary\|New Zealand\|Poland\|Romania\|Russian Federation\|Slovakia\|Turkey\|United Kingdom	1
United States\|Argentina\|Austria\|Canada\|China\|Croatia\|Greece\|Ireland\|Japan\|Korea, Republic of\|Malaysia\|Netherlands\|Portugal\|Romania\|Spain\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
United States\|Argentina\|Belgium\|Canada\|Czechia\|Denmark\|Finland\|France\|Germany\|Hungary\|Israel\|Italy\|Japan\|Mexico\|Netherlands\|Poland\|Puerto Rico\|Russian Federation\|Spain\|United Kingdom	1
United States\|Argentina\|Belgium\|Canada\|France\|Germany\|Netherlands\|Poland\|United Kingdom	1
United States\|Australia	1
United States\|Australia\|Austria\|Belgium\|Canada\|China\|Czechia\|France\|Germany\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Poland\|Portugal\|Russian Federation\|Singapore\|Spain\|Taiwan\|Ukraine	1
United States\|Australia\|Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Russian Federation\|Spain\|Ukraine	1
United States\|Australia\|Belgium\|Brazil\|Canada\|Chile\|China\|Colombia\|France\|Germany\|Israel\|Italy\|Japan\|Korea, Republic of\|Mexico\|Peru\|Poland\|Spain\|Taiwan\|United Kingdom	1
United States\|Australia\|Belgium\|Brazil\|Canada\|Czech Republic\|Greece\|Korea, Republic of\|New Zealand\|Poland\|Portugal\|Romania\|Russian Federation\|Spain	1
United States\|Australia\|Belgium\|Brazil\|Czechia\|France\|Germany\|Hungary\|Italy\|Spain	1
United States\|Australia\|Belgium\|Canada\|Germany\|Italy\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Hong Kong\|Italy\|Korea, Republic of\|Poland\|Russian Federation\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Chile\|Colombia\|Czechia\|France\|Germany\|Hungary\|Italy\|Peru\|Poland\|Romania\|Spain\|Turkey\|United Kingdom	1
United States\|Australia\|Belgium\|Czechia\|France\|Germany\|Italy\|Korea, Republic of\|Poland\|Spain	1
United States\|Australia\|Belgium\|France\|Hungary\|Italy\|Poland\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|France\|Israel\|Spain\|Taiwan\|United Kingdom	1
United States\|Australia\|Brazil\|Canada\|Chile\|China\|Colombia\|France\|Guatemala\|Hong Kong\|Ireland\|Israel\|Japan\|Korea, Republic of\|Mexico\|New Zealand\|Peru\|Poland\|Russian Federation\|South Africa\|Spain\|Switzerland\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
United States\|Australia\|Brazil\|Canada\|France\|Germany\|Hungary\|Italy\|Japan\|Korea, Republic of\|Romania\|Russian Federation\|Spain\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
United States\|Australia\|Brazil\|Chile\|China\|France\|Germany\|Guatemala\|Ireland\|Israel\|Italy\|Japan\|Korea, Republic of\|New Zealand\|Poland\|Russian Federation\|Spain\|Turkey\|Ukraine\|United Kingdom	1
United States\|Australia\|Canada\|Germany\|Italy\|Poland\|Russian Federation\|Spain	1
United States\|Australia\|Canada\|Ireland\|New Zealand\|Peru\|Puerto Rico\|United Kingdom	1
United States\|Australia\|Canada\|Japan\|Singapore\|Spain\|United Kingdom	1
United States\|Australia\|China\|Japan	1
United States\|Australia\|France\|Ireland\|Italy\|Japan\|Korea, Republic of\|Spain\|Taiwan	1
United States\|Australia\|France\|Japan	1
United States\|Australia\|Korea, Republic of\|Taiwan	1
United States\|Australia\|New Zealand\|Poland\|Thailand	1
United States\|Australia\|Norway\|Spain	1
United States\|Australia\|Singapore	1
United States\|Australia\|Spain	1
United States\|Austria\|Canada\|Czechia\|France\|Hungary\|Israel\|Italy\|Poland\|Spain\|Switzerland	1
United States\|Belgium	1
United States\|Belgium\|Brazil\|Canada\|Chile\|France\|Germany\|Israel\|Italy\|Japan\|Korea, Republic of\|Malaysia\|Poland\|Russian Federation\|Singapore\|Taiwan\|Ukraine\|United Kingdom	1
United States\|Belgium\|Canada\|Czechia\|Germany\|Greece\|Italy\|Spain\|Sweden\|Turkey\|Ukraine	1
United States\|Belgium\|Canada\|France\|Israel\|Italy\|Singapore\|Spain\|Taiwan	1
United States\|Belgium\|Canada\|Israel	1
United States\|Belgium\|Canada\|Spain	1
United States\|Belgium\|France\|Germany\|Italy\|Korea, Republic of\|Spain\|United Kingdom	1
United States\|Belgium\|Italy	1
United States\|Belgium\|Italy\|Spain\|United Kingdom	1
United States\|Belgium\|Korea, Republic of\|Netherlands\|Poland	1
United States\|Belgium\|United Kingdom	1
United States\|Bulgaria\|Poland\|Romania\|Russian Federation\|Ukraine	1
United States\|Canada\|France	1
United States\|Canada\|France\|Germany\|Hungary\|Spain	1
United States\|Canada\|France\|Germany\|Mexico\|Poland\|Russian Federation	1
United States\|Canada\|France\|Netherlands	1
United States\|Canada\|France\|Netherlands\|United Kingdom	1
United States\|Canada\|Germany\|Korea, Republic of\|Netherlands\|Spain	1
United States\|Canada\|Hong Kong	1
United States\|Canada\|Ireland\|Switzerland	1
United States\|Canada\|Japan\|Korea, Republic of\|Puerto Rico	1
United States\|Canada\|Japan\|Korea, Republic of\|Singapore\|Taiwan	1
United States\|Canada\|Peru\|Puerto Rico\|South Africa	1
United States\|Canada\|Peru\|South Africa	1
United States\|Canada\|Singapore	1
United States\|Chile\|Denmark\|Estonia\|France\|Hungary\|Italy\|Korea, Republic of\|Russian Federation\|Taiwan\|Turkey	1
United States\|China\|France\|Italy\|Japan\|Korea, Republic of\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Spain\|Taiwan\|Turkey\|United Kingdom	1
United States\|Czech Republic\|France\|Poland\|Spain\|United Kingdom	1
United States\|Denmark\|France\|Spain	1
United States\|Finland\|Netherlands\|Sweden\|United Kingdom	1
United States\|France\|Germany\|Hong Kong\|Italy\|Japan\|Korea, Republic of\|Poland\|Russian Federation\|Singapore\|Spain\|Taiwan	1
United States\|France\|Germany\|Israel\|Italy\|Korea, Republic of\|Spain\|Taiwan	1
United States\|France\|Germany\|Italy\|Japan\|Korea, Republic of\|Poland\|Romania\|Russian Federation\|Taiwan\|Ukraine\|United Kingdom	1
United States\|France\|Germany\|Japan\|Spain\|United Kingdom	1
United States\|France\|Germany\|Korea, Republic of\|Netherlands\|Spain\|Taiwan\|United Kingdom	1
United States\|France\|Hungary\|Israel\|Korea, Republic of\|Romania\|Russian Federation\|Taiwan	1
United States\|France\|Israel\|Korea, Republic of	1
United States\|France\|Italy\|Korea, Republic of\|Taiwan	1
United States\|France\|United Kingdom	1
United States\|Germany\|Korea, Republic of\|Netherlands\|Spain\|Taiwan\|United Kingdom	1
United States\|Germany\|Korea, Republic of\|Spain	1
United States\|Hong Kong\|Japan\|Korea, Republic of\|Taiwan	1
United States\|Hong Kong\|Japan\|Singapore\|Taiwan	1
United States\|Hungary\|India\|Russian Federation\|Ukraine	1
United States\|Israel\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Chile\|Estonia\|France\|Germany\|Hungary\|Italy\|Japan\|Korea, Republic of\|Lithuania\|Mexico\|Poland\|Portugal\|Romania\|Russian Federation\|Singapore\|Spain\|Taiwan\|United Kingdom	1
United States\|Israel\|Korea, Republic of\|Spain	1
United States\|Italy	1
United States\|Korea, Republic of\|Spain\|United Kingdom	1
United States\|Netherlands\|Peru	1
United States\|Norway\|Spain\|United Kingdom	1
United States\|Peru\|South Africa	1
United States\|Russian Federation	1
United States\|South Africa	1
Vietnam	1

Site_count	Study_Count
1	119
2	9
3	5
4	6
5	3
6	1
7	4
8	2
9	3
10	3
12	2
13	1
14	2
16	3
17	1
18	2
19	1
22	1
36	1
57	1
66	1
101	1
143	1

Count of Versions	Count of Studies
1	38
2	32
3	22
4	14
5	9
6	12
7	4
8	7
9	4
10	2
11	6
12	2
13	1
14	3
16	1
17	2
18	3
20	2
21	1
24	2
51	1
52	1
54	1
66	1
72	1
110	1

Site_count	Study_Count
1	119
2	9
3	5
4	6
5	3
6	1
7	4
8	2
9	3
10	3
12	2
13	1
14	2
16	3
17	1
18	2
19	1
22	1
36	1
57	1
66	1
101	1
143	1

Count of Versions	Count of Studies
1	38
2	32
3	22
4	14
5	9
6	12
7	4
8	7
9	4
10	2
11	6
12	2
13	1
14	3
16	1
17	2
18	3
20	2
21	1
24	2
51	1
52	1
54	1
66	1
72	1
110	1

adenocarcinoma

Study Counts

Studies over Time

Interventional Trials

Intervention Type

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Studies by Country

Sites per Study

Phase

Number of Arms

Number of Updates

Update History Change Type

Enrollment Metrics by Phase

Trial Group Type

Intervention Model

Primary Purpose

Observational Studies

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Observation Model

Time Perspective

Registries

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Registry Model

Time Perspective

Follow-up

Site_count	Study_Count
1	119
2	9
3	5
4	6
5	3
6	1
7	4
8	2
9	3
10	3
12	2
13	1
14	2
16	3
17	1
18	2
19	1
22	1
36	1
57	1
66	1
101	1
143	1

Count of Versions	Count of Studies
1	38
2	32
3	22
4	14
5	9
6	12
7	4
8	7
9	4
10	2
11	6
12	2
13	1
14	3
16	1
17	2
18	3
20	2
21	1
24	2
51	1
52	1
54	1
66	1
72	1
110	1